Believers in DeepTech to Radically Change Healthcare Outcomes
Investing in extraordinary pre-seed and seed founders
Our Beliefs
We believe the future of healthcare will be shaped by bold innovation, long-term thinking, and founders who don’t just follow trends—they set them. Our beliefs guide how we invest, support, and build alongside visionary founders
Innovation with Depth:
We’re optimistic about healthcare’s future. The 4th Industrial Revolution brings a rare opportunity to radically improve outcomes. We launched AioT Health in Fall 2019, years before ChatGPT, because we saw AI as a general-purpose technology that could meaningfully shape healthcare. Today, we’re focused on how AI unlocks deep tech like robotics, quantum computing, and synthetic biology. We’ve been ahead of the curve—and we’re just getting started
Our Golden Circle:
We focus on why a company exists, not just what it does. Purpose-led founders attract lasting talent, partners, and capital. This principle shapes how we invest and build
Why: We aim to compound knowledge in healthcare innovation, relationships, and capital
How: Fluency in science, medicine, and venture
What: AioT Health is an early-stage VC fund investing in AI-driven healthcare innovators
Compounding Knowledge, Relationships & Capital:
We compound capital, knowledge, and relationships by investing in founders reimagining the future of healthcare. Each company, insight, and connection fuels long-term momentum across the portfolio
Impact That Matters:
We believe the true measure of innovation is its ability to improve lives. That’s why we back founders who are expanding access, reducing disparities, and driving better health outcomes—especially for those historically underserved. We believe AI isn’t just raising the ceiling of what's possible in healthcare—it’s helping raise the floor by making high-quality care more scalable, consistent, and accessible across systems and populations
What We Look For In Ventures
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Non-consensus opinions
Breakthroughs in healthcare don’t come from following the crowd. They come from founders with bold ideas that challenge convention. We invest in non-consensus ideas with the potential to radically improve health outcomes
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Category defining companies
We look for extraordinary founders with a vision to reshape entire domains, not just fix isolated problems. We invest in companies with a long-term vision: those defining entirely new categories of care
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Virtuous Data Cycles
We invest in ventures where data isn’t a byproduct, it’s the engine. These companies use data to drive better outcomes, smarter products, and deeper moats. Each interaction makes the system stronger, creating self-reinforcing loops that compound value over time
Customer purchases product because of proven utility
Use of product generates data automatically back to the company
Virtuous Data Cycles
Data leads to company improving the product for current and future customers
Our Portfolio
Probius is transforming diagnostics with a point-of-care platform that uses Quantum Electrochemical Spectroscopy and machine learning to detect biomarkers by their unique vibrations. Its proprietary digital twin library reveals hidden biological insights from a single sample, enabling deeper discovery and understanding.
DrugBank enables data-driven precision medicine by using natural language processing and knowledge algorithms to extract and connect clinical and molecular data. Its platform reveals drug interactions with genotypes, phenotypes, and diseases—advancing personalized treatment insights.
SeamlessMD provides a digital platform designed to modernize patient involvement in healthcare. It enhances patient engagement, tracks progress, and enables remote monitoring—seamlessly guiding patients through their care journeys across surgery, oncology, and chronic disease management.
Trexo Robotics builds gait-assist devices that help children with neurodevelopmental delays walk, often for the first time. Sensor data drives continuous improvement and future expansion into mobility solutions for the elderly.
DrugBank enables data-driven precision medicine by using natural language processing and knowledge algorithms to extract and connect clinical and molecular data. Its platform reveals drug interactions with genotypes, phenotypes, and diseases—advancing personalized treatment insights.
Alio is a wearable patch that noninvasively tracks vital signs and lab biomarkers in real time, helping prevent complications in dialysis care by wirelessly transmitting data to EMRs; the company is also expanding into defense and high-performance athletics.
Sanctuary AI has as a bold vision combining Artificial General Intelligence & Robotics to build “intelligent machines” that can perform economically valuable tasks. AioT Health invested in the Seed and Series A Rounds.
Arcascope applies algorithms to data from wearables to determine personalized circadian rhythms in order to optimize sleep-wake schedules. Arcascope is at the forefront of chronomedicine, where the impact of therapies can be improved by synchronizing with circadian rhythms.
Innovere Medical advances brain research with MRI-compatible hardware and a future software platform for exploring brain connectivity. Its flagship product, Innovision, lets patients watch streaming content during scans for a more comfortable MRI experience.
Our Team
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Jehangir Appoo, MD
Founding Partner
Jehangir combines 2 decades of expertise at the front lines of health care & academia with experience in value investing to match the algorithm with the right clinical problem
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Matt Mayer, BCom, MSc, DBA
Principal
Matt is a two-time entrepreneur with over a decade of strategic consulting experience, specializing in scaling businesses with impact-driven models
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Ali Ardakani
Venture Partner
Ali brings over 20 years of experience in life sciences commercialization, pharmaceutical partnerships, and global mergers and acquisitions